Once the world's largest operator of the 747, BA has now retired its entire jumbo jet fleet after COVID-19 curtailed most air travel, accelerating the move to more fuel-efficient planes.
The airline had planned a rarely seen synchronised dual take off on parallel Heathrow runways but the weather prevented that. The final flights were witnessed by BA staff and engineers who lined up to see them off.
For over 50 years, the 747 has been the world's most easily recognised jetliner with its humped fuselage, four engines and 16 main wheels.
It took its maiden flight in 1969 and soon secured its place in history as the jet which allowed more affordable air travel due its size and range.
Set your alarm clocks for 07:40 UK BST tomorrow, as we say one last goodbye to our "Queen of the Skies" from Heathrow. Join us virtually and share your memories from 7:47am with #BA747farewell. This is something you won’t want to miss! Watch live at https://t.co/80oCAscmLE. pic.twitter.com/nOYRBmSaDG— British Airways (@British_Airways) October 7, 2020
Passengers have included John Paul II, who arrived for the first visit to Ireland by a pope on an Aer Lingus 747 in 1979. Ayatollah Ruhollah Khomeini returned to Iran from exile on an Air France jumbo during the Islamic Revolution that year.
BA's predecessor BOAC introduced the 747 on the London-New York route in 1971, and at its peak BA had 57 747-400s.
Former pilots have told how the jet took some getting used to, from a cockpit positioned almost 30 feet above the ground and more when angling the nose higher just before touching the runway.
"It was like landing a block of flats from the 2nd floor," Hugh Dibley, a former BOAC captain, told Reuters.
The owner of British Airways, IAG, is battling to survive after the pandemic wiped out much of the global flying market.